The effect of protein-energy malnutrition on the absorption, distribution and elimination of chloroquine in the rat
Identifieur interne : 003689 ( Main/Exploration ); précédent : 003688; suivant : 003690The effect of protein-energy malnutrition on the absorption, distribution and elimination of chloroquine in the rat
Auteurs : S. A. Adelusi [Nigeria] ; L. A. Salako [Nigeria]Source :
- General Pharmacology [ 0306-3623 ] ; 1982.
English descriptors
- Teeft :
- Adelusi salako, Blood cell, Blood cells, Cassavabased diet, Chloroquine, Chloroquine content, Chloroquine kinetics, Chloroquine metabolism, Concentration time curves, Control rats, Dietary group, Different groups, Equal volume, Kinetics, Kwashiorkorigenic, Kwashiorkorigenic diet, Laboratory studies, Malnourished, Malnourished rats, Mcchesney, Normal diet, Normal rats, Normal saline, Protein content, Protein malnutrition, Rat, Refed, Refed rats, Salako, Significant difference, Single dose, Skeletal muscle, Smaller number, Various tissues, Wharton mcchesney.
Abstract
Abstract: 1. Protein-energy malnutrition was induced in young rats by feeding them a protein-deficient diet. 2. The kinetics of uptake and elimination of chloroquine in various tissues were compared in normal rats, malnourished rats, and malnourished rats after recovery from malnutrition. 3. In the blood, liver, spleen, heart, kidney and skeletal muscle, uptake of chloroquine was slower in malnourished than in normal rats. Chloroquine was also eliminated at a slower rate in malnourished rats. In the skin chloroquine was taken up to a greater extent in malnourished than in normal rats. 4. When malnourished rats were allowed to recover from their state of malnutrition, the uptake and elimination of chloroquine no longer differed from those of animals that had never been malnourished.
Url:
DOI: 10.1016/0306-3623(82)90025-8
Affiliations:
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A." last="Adelusi">S. A. Adelusi</name><affiliation wicri:level="4"><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan</wicri:regionArea><orgName type="university">Université d'Ibadan</orgName><placeName><settlement type="city">Ibadan</settlement><region type="region">État d'Oyo</region></placeName></affiliation></author><author><name sortKey="Salako, L A" sort="Salako, L A" uniqKey="Salako L" first="L. A." last="Salako">L. A. 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Protein-energy malnutrition was induced in young rats by feeding them a protein-deficient diet. 2. The kinetics of uptake and elimination of chloroquine in various tissues were compared in normal rats, malnourished rats, and malnourished rats after recovery from malnutrition. 3. In the blood, liver, spleen, heart, kidney and skeletal muscle, uptake of chloroquine was slower in malnourished than in normal rats. Chloroquine was also eliminated at a slower rate in malnourished rats. In the skin chloroquine was taken up to a greater extent in malnourished than in normal rats. 4. When malnourished rats were allowed to recover from their state of malnutrition, the uptake and elimination of chloroquine no longer differed from those of animals that had never been malnourished.</div></front></TEI><affiliations><list><country><li>Nigeria</li></country><region><li>État d'Oyo</li></region><settlement><li>Ibadan</li></settlement><orgName><li>Université d'Ibadan</li></orgName></list><tree><country name="Nigeria"><region name="État d'Oyo"><name sortKey="Adelusi, S A" sort="Adelusi, S A" uniqKey="Adelusi S" first="S. A." last="Adelusi">S. A. Adelusi</name></region><name sortKey="Salako, L A" sort="Salako, L A" uniqKey="Salako L" first="L. A." last="Salako">L. A. Salako</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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